Figure 2
From: Histopathologic findings associated with APOL1 risk variants in chronic kidney disease
Renal biopsy findings in African Americans with hypertension, nephrosclerosis, and stage ≥3 CKD. (a) Tubules with classic-type tubular atrophy show thickened and wrinkled basement membranes with occasional basement membrane lamellation (periodic acid–Schiff, original magnification × 400). (b) Tubules with thyroidization-type atrophy have a luminal hyaline cast surrounded by simplified epithelium (periodic acid–Schiff, original magnification × 200). (c) Endocrine-type tubular atrophy with narrow or no tubular lumen, clear cytoplasm, and thin basement membranes (periodic acid–Schiff, original magnification × 400). (d) Glomerulus showing ischemic obsolescence with contracted sclerotic tuft and surrounding fibrosis in Bowman’s space surrounded by intact Bowman’s capsule (periodic acid–Schiff, original magnification × 400). (e) Disappearing pattern of glomerulosclerosis with complete disappearance of Bowman’s capsule and the sclerotic glomerular tuft beginning to blend with background fibrosis (periodic acid–Schiff, original magnification × 400). (f) Solidified glomerulosclerosis in which the sclerotic tuft is not contracted and fills Bowman’s space (periodic acid–Schiff, original magnification × 400).
