Table 2 Renal biopsy findings in the validation phase
From: Histopathologic findings associated with APOL1 risk variants in chronic kidney disease
Morphologic finding | 0 APOL1 RA | 1 APOL1 RA | 2 APOL1 RA | P (2 vs 0/1) | P (1 vs 0) | P (2 vs 1) |
|---|---|---|---|---|---|---|
No. of patients | 23 | 25 | 34 | |||
Mean age (range) | 55 (33–88) | 52 (28–91) | 48 (15–73) | 0.1 | 0.5 | 0.3 |
Solidified +disappearing predominant GS | 5 (22%) | 9 (36%) | 20 (59%) | 0.01 | 0.4 | 0.1 |
Cases with segmental glomerulosclerosis | 7 (30%) | 13 (52%) | 21 (62%) | 0.1 | 0.2 | 0.6 |
Cases with severe tubular atrophy | 9 (39%) | 10 (40%) | 24 (71%) | 0.01 | 0.8 | 0.04 |
Cases with thyroidization-dominant TA | 1 (4%) | 4 (16%) | 8 (24%) | 0.2 | 0.3 | 0.5 |
Cases with microcystic tubular dilatation | 2 (9%) | 6 (24%) | 13 (38%) | 0.05 | 0.3 | 0.4 |
Cases with severe arteriosclerosis | 17 (74%) | 15 (60%) | 19 (56%) | 0.4 | 0.5 | 0.9 |
Cases with severe arteriolar hyalinosis | 6 (26%) | 6 (24%) | 9 (26%) | 0.9 | 0.9 | 0.9 |
