Table 3 Renal biopsy findings in the combined discovery and validation samples
From: Histopathologic findings associated with APOL1 risk variants in chronic kidney disease
Morphologic finding | 0 APOL1 RA | 1 APOL1 RA | 2 APOL1 RA | P (2 vs 0/1) | P (1 vs 0) | P (2 vs 1) |
|---|---|---|---|---|---|---|
No. of patients | 79 | 25 | 92 | |||
Mean age (range) | 56 (15–84) | 52 (28–91) | 47 (33–88) | <0.001 | 0.4 | 0.1 |
Serum Cr mean, mg/dl (N) | 3.8 (61) | 3.6 (22) | 4.3 (64) | 0.3 | 0.7 | 0.4 |
24 h proteinuria, mean g/day (N) | 3.1 (30) | 2.4 (11) | 3.9 (40) | 0.1 | 0.4 | 0.1 |
Solidified+disappearing predominant GS | 27 (34%) | 9 (36%) | 62 (67%) | 0.01 | 0.3 | 0.01 |
Cases with segmental glomerulosclerosis | 51 (65%) | 13 (52%) | 64 (70%) | 0.3 | 0.4 | 0.2 |
Cases with severe tubular atrophy | 36 (46%) | 10 (40%) | 64 (70%) | 0.001 | 0.8 | 0.01 |
Cases with thyroidization-dominant TA | 9 (11%) | 4 (16%) | 30 (33%) | 0.001 | 0.8 | 0.2 |
Cases with microcystic tubular dilatation | 6 (8%) | 6 (24%) | 31 (34%) | <0.001 | 0.06 | 0.5 |
Cases with severe arteriosclerosis | 49 (62%) | 15 (60%) | 40 (43%) | 0.1 | 0.9 | 0.2 |
Cases with severe arteriolar hyalinosis | 21 (27%) | 6 (24%) | 14 (15%) | 0.1 | 0.9 | 0.5 |
