Table 1 Comparision of clinical features of atypical and typical MYC/BCL2 DHL

From: B-cell lymphomas with concurrent MYC and BCL2 abnormalities other than translocations behave similarly to MYC/BCL2 double-hit lymphomas

Features

Atypical MYC/BCL2 DHL

MYC/BCL2 DHL

Age (years), median (range)

60 (6–82)

61 (18–87)

Age>60 (years)

53% (21/41)

55% (42/76)

Male:female

21:19

47:29

Previous FL/B-NHL

23% (9/40)

27% (20/72)

BM positive

40% (8/20)

55% (38/69)

CNS positive

9% (1/11)

20% (7/35)

Extranodal sites≥2

52% (14/27)

58% (39/67)

Elevated serum LDH*

55% (16/29)

79% (52/66)

Stage III or IV

71% (22/31)

84% (62/74)

High IPI score

60% (18/30)

76% (54/71)

  1. Abbreviations: BM, bone marrow; B-NHL, B-cell non-Hodgkin lymphoma; CNS, central nervous system; DHL, double-hit lymphoma; FL, follicular lymphoma; IPI, International Prognostic Index; LDH, lactate dehydrogenase.
  2. *P=0.01.
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