Table 5 Comparison of clinical features of patients with atypical MYC/BCL2 DHL and patients with DLBCL with normal MYC and BCL2

From: B-cell lymphomas with concurrent MYC and BCL2 abnormalities other than translocations behave similarly to MYC/BCL2 double-hit lymphomas

Features

Atypical MYC/BCL2 DHL

MYC/BCL2 Normal DLBCL

Age (years), median (range)

60 (6–82)

63 (3–87)

Age>60 (years)

53% (21/40)

54% (19/35)

Male:female

21:19

20:15

Previous FL/B-NHL

23% (9/40)

9% (3/35)

BM positive

40% (8/20)

16% (4/25)

CNS positive

9% (1/11)

0% (0/14)

Extranodal sites≥2*

52% (14/27)

20% (8/40)

Elevated serum LDH

55% (16/29)

45% (14/31)

Stage III or IV*

71% (22/31)

43% (13/30)

High IPI score*

60% (18/30)

32% (9/28)

  1. Abbreviations: BM, bone marrow; B-NHL, B-cell non-Hodgkin lymphoma; CNS, central nervous system; DHL, double-hit lymphoma; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; IPI, International Prognostic Index; LDH, lactate dehydrogenase.
  2. *P<0.05.
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