Table 3 Correlations between tumor PD-L1 and lymphocyte markers

From: Tumor PD-L1 expression, immune cell correlates and PD-1+ lymphocytes in sentinel lymph node melanoma metastases

Spearman’s Rho	% PD-L1	PD1 (Peritumoral)	PD1 (Intratumoral)	CD3 (Peritumoral)	CD3 (Intratumoral)	CD4 (Peritumoral)	CD4 (Intratumoral)	CD8 (Peritumoral)	CD8 (Intratumoral)	FOXP3 (Peritumoral)	FOXP3 (Intratumoral)
% PD-L1
Coefficient (x)		0.311 ^a	0.425 ^b	0.164	0.329 ^a	0.209	0.155	0.256 ^a	0.448 ^b	0.351 ^b	0.395 ^b
Sig. (2-tailed)		0.016	0.001	0.214	0.011	0.112	0.241	0.048	0.000	0.006	0.002
PD1 (Peritumoral)
Correlation (x)	0.311^a		0.584 ^b	0.163	0.141	0.384 ^b	0.154	0.343 ^b	0.220	0.459 ^b	0.224
Sig. (2-tailed)	0.016		0.000	0.217	0.287	0.003	0.243	0.007	0.092	0.000	0.088
PD1 (Intratumoral)
Coefficient (x)	0.425^b	0.584^b		0.288 ^a	0.632 ^b	0.226	0.315 ^a	0.387 ^b	0.696 ^b	0.431 ^b	0.658 ^b
Sig. (2-tailed)	0.001	0.000		0.029	0.000	0.088	0.016	0.002	0.000	0.001	0.000
CD3 (Peritumoral)
Coefficient (x)	0.164	0.163	0.288^a		0.441 ^b	0.361 ^b	0.247	0.698 ^b	0.364 ^b	0.438 ^b	0.326 ^a
Sig. (2-tailed)	0.214	0.217	0.029		0.000	0.005	0.062	0.000	0.005	0.001	0.013
CD3 (Intratumoral)
Coefficient (x)	0.329^a	0.141	0.632^b	0.441^b		0.162	0.436 ^b	0.265 ^a	0.928 ^b	0.221	0.721 ^b
Sig. (2-tailed)	0.011	0.287	0.000	0.000		0.224	0.001	0.043	0.000	0.096	0.000
CD4 (Peritumoral)
Coefficient (x)	0.209	0.384^b	0.226	0.361^b	0.162		0.596 ^b	0.154	0.120	0.181	0.183
Sig. (2-tailed)	0.112	0.003	0.088	0.005	0.224		0.000	0.245	0.366	0.174	0.170
CD4 (Intratumoral)
Coefficient (x)	0.155	0.154	0.315^a	0.247	0.436^b	0.596^b		0.032	0.391 ^b	0.173	0.437 ^b
Sig. (2-tailed)	0.241	0.243	0.016	0.062	0.001	0.000		0.812	0.002	0.194	0.001
CD8 (Peritumoral)
Coefficient (x)	0.256^a	0.343^b	0.387^b	0.698^b	0.265^a	0.154	0.032		0.338 ^b	0.493 ^b	0.219
Sig. (2-tailed)	0.048	0.007	0.002	0.000	0.043	0.245	0.812		0.008	0.000	0.096
CD8 (Intratumoral)
Coefficient (x)	0.448^b	0.220	0.696^b	0.364^b	0.928^b	0.120	0.391^b	0.338^b		0.302 ^a	0.771 ^b
Sig. (2-tailed)	0.000	0.092	0.000	0.005	0.000	0.366	0.002	0.008		0.020	0.000
FOXP3 (Peritumoral)
Coefficient (x)	0.351^b	0.459^b	0.431^b	0.438^b	0.221	0.181	0.173	0.493^b	0.302^a		0.520 ^b
Sig. (2-tailed)	0.006	0.000	0.001	0.001	0.096	0.174	0.194	0.000	0.020		0.000
FOXP3 (Intratumoral)
Coefficient (x)	0.395^b	0.224	0.658^b	0.326^a	0.721^b	0.183	0.437^b	0.219	0.771^b	0.520^b
Sig. (2-tailed)	0.002	0.088	0.000	0.013	0.000	0.170	0.001	0.096	0.000	0.000

^aCorrelation is significant at the 0.05 level (two-tailed).
^bCorrelation is significant at the 0.01 level (two-tailed). Italic values signify cases that had a correlation coefficient (x) of 0.25–0.5 and bold values signify samples with a correlation coefficient (x) >0.5.

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Table 3 Correlations between tumor PD-L1 and lymphocyte markers

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