Table 2 Pathological characteristics
From: Renal extramedullary hematopoiesis: interstitial and glomerular pathology
Patient | Biopsy diagnosis | Glomerular pattern | Location of EMH | ATI | Interstitial fibrosis | IF | Electron microscopy |
|---|---|---|---|---|---|---|---|
1 | EMH, ‘LHCDD by IF only’ | Mild mesangial sclerosis | Interstitium, diffuse | No | None | Linear GBM and TBM with IgG (2+), kappa (2+), and lambda (trace) | Normal, preserved podocyte FP; no evidence of MIDD |
2 | FSGS, EMH | FSGS, segmental endothelial injury by EM | Perirenal soft tissue | No | Moderate | Negative | Moderate segmental FPE; segmental endothelial injury |
3 | Diabetic glomerulosclerosis and TMA, EMH | Diffuse mesangial sclerosis, segmental GBM duplication, FSGS | Interstitium, diffuse | Yes | Mild | Negative | Diffuse FPE; segmental TMA features |
4 | Fibrillary-like glomerulonephritis and TMA, EMH | Moderate mesangial sclerosis, segmental GBM duplication; Congo red-negative | Interstitium, diffuse | Yes | Mild | Granular mesangial and segmental GBM IgM(2+), IgA(1+), kappa(1+), lambda(1+), and C3(2+) | Diffuse FPE, mesangial and GBM fibrillary deposits 15–20 nm diameter; segmental TMA features |
5 | FSGS, EMH | FSGS, increased global glomerulosclerosis (50%) | Perirenal soft tissue, interstitium (medulla), focal, on previous biopsy | No | Mild | NA, inadequate tissue | Diffuse FPE |
6 | EMH | NA (fine-needle aspirate) | NA | NA | NA | NA | NA |
7 | Fibrillary-like glomerulonephritis, EMH | Mild mesangial hypercellularity, moderate mesangial sclerosis; Congo red-negative | Interstitium, diffuse | None | Moderate | Granular glomerular IgM(1–2+) and C3 (1–2+) | Diffuse FPE; mesangial and GBM fibrillary deposits 11 nm diameter |
8 | EMH | Normal | Perirenal soft tissue, interstitium, focal | No | Moderate | Negative | Moderate segmental FPE (ischemic) |
9 | TMA, diabetic glomerulosclerosis, EMH, | Nodular mesangial sclerosis | Perirenal soft tissue, interstitium, focal | No | Moderate | Negative | TMA features segmental mild FPE |
10 | FSGS, EMH | FSGS, increased global glomerulosclerosis (56%), mild-moderate mesangial sclerosis | Interstitium, multifocal | Yes | Severe | Negative | Diffuse FPE |
11 | FSGS, EMH | FSGS, increased global glomerulosclerosis (32%), mild-moderate mesangial sclerosis, segmental endothelial injury by EM | Interstitium, diffuse | No | Moderate | Negative | Segmental FPE; segmental endothelial injury |
12 | Light-chain cast nephropathy, EMH | NA, normal; Congo red-negative | Interstitium, diffuse | Yes | Mild | Granular mesangial C3 (trace); casts lambda (3+), and kappa negative | Segmental mild FPE |
13 | Fibrillary-like glomerulonephritis, TMA, EMH | Mesangiolysis, mild mesangial sclerosis, segmental GBM duplication; Congo red weakly positive | Interstitium, diffuse | Yes | Mild | Negative | Diffuse FPE; mesangial and GBM fibrillary deposits 13 nm diameter; segmental GBM multilayering |
14 | TMA, EMH | Mesangiolysis, mild mesangial sclerosis, global GBM duplication | Interstitium, focal. Peritubular capillaries with circulating megakaryocytes and erythroid precursors | Yes | Moderate | Negative | Diffuse FPE; segmental GBM duplication |
