Figure 4

(a–d) Myc overexpression was correlated with significantly higher levels of MDM2, IRF4, and MME/CD10 mRNA expression in germinal center B-cell-like (GCB) diffuse large B-cell lymphoma and significantly higher levels of FOXP1 and IRF4 mRNA expression in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL). (e) The MYC-R⁺/Myc^high compared with MYC-R⁻/Myc^high group had significantly lower levels of MUM1 expression. (f–j) The MDM2, CD30, CD10, and FOXP1 levels in Myc^high GCB-DLBCL patients with MYC translocation were significantly different from those of Myc^high GCB-DLBCL patients without MYC translocation. (k and l) The Bcl-6 and pAKT levels of Myc^high ABC-DLBCL patients with MYC translocation were significantly lower compared with those of Myc^high ABC-DLBCL patients without MYC translocation. Myc^high, high Myc protein expression; Myc^low, low Myc protein expression; MYC-R⁺, MYC rearrangement-positive; MYC-R⁻, MYC rearrangement-negative; MYC-R^N/A, MYC rearrangement status not available.