Table 3 Gene expression profile signatures of Myc protein overexpression in GCB-DLBCL

From: Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP

Functional categories

Upregulated

Downregulated

1. MYC-R + /Myc high vs Myc low GCB-DLBCL (false discovery rate <0.01, fold change >2.38)

 Signaling

 

TRAF1, DUSP4, GABBR1/UBD

 Cell proliferation and growth, gene expression

MYC, SMAD1, BACH2, STRBP

FAM129A

 Metabolism

 

NNMT

 Cell death

PEG10, ZNF385B

BCL2A1, TMEM49

 Immune response, anti-viral/anti-microbial activities

IGJ, DKFZp686O24166/ NCR3LG1

CD58, GBP1, SLAMF7, LYZ

 Cell adhesion, extracellular matrix, migration

 

FN1, BGN, CD44

 microRNAs

 

MIR21, MIR155HG

 Unknown function

TPD52

 

2. MYC-R−/ Mychigh vs Myclow GCB-DLBCL (false discovery rate <0.30, fold change >1.2)

 Signaling

RGS8, GPS1, FAM123A, PDLIM7

 

 Cell proliferation and growth, gene expression, ribosome biogenesis

C9orf100, SMARCA4, ZNF8, MRPS12, EMG1, INTS1

 

 Metabolism

SLC25A27, FADS2, ACAD9

 

 Microtubules, migration, cell interaction

TUBB2C, TUBB3

LGALS8

 Transport

ABCA4, CHCHD4

VPS36

 Long noncoding RNA, RNA gene

NAPSB

LOC202181, LOC440944

3. MYC-R+/Mychigh vs MYC-R−/Mychigh GCB-DLBCL (false discovery rate <0.30, fold change >1.3)

 Signaling

SIKE1

SPRED1

 Transcription, ribosome biogenesis

NAF1, RRP1B, SMAD1

FOXN3, ATN1

 Metabolism

GANC

 

 Extracellular matrix, migration, cytoskeleton

 

BGN, TRIOBP

 Unknown function

PWWP2A

KIAA0913

  1. Abbreviations: DLBCL, diffuse large B-cell lymphoma; GCB, germinal-center-B-cell-like; MYC-R+, MYC rearrangement-positive; MYC-R−, MYC rearrangement-negative; Mychigh, high Myc protein expression; Myclow, low Myc protein expression.
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