Figure 1

Dual-color fluorescence in situ hybridization using locus-specific probes for CDKN2A (orange) and NF2 (red) and chromosome 9 centromeric and chromosome 22 centromeric probes (green), respectively. Representative examples of peritoneal mesotheliomas with a normal copy number for CDKN2A (a) and NF2 (c). In contrast, homozygous deletions in CDKN2A were characterized by loss of both orange signals, but retention of at least one green signal (b). Hemizygous NF2 loss consisted of either monosomy at chromosome 22 (one red and green signal, (d)) or hemizygous deletion in NF2 (one red and two green signals, data not shown).