Table 1 Clinical and pathologic features of 86 peritoneal mesotheliomas with respect to CDKN2A and NF2 status
From: The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma
Patient or tumor characteristics | Total, n=86 | CDKN2A | NF2 | ||||
|---|---|---|---|---|---|---|---|
Wild type | Homozygous deletion | P-value | Wild type | Hemizygous loss | P-value | ||
Gender | |||||||
Female | 26 (30%) | 18 (30%) | 8 (32%) | 0.802 | 15 (27%) | 11 (37%) | 0.460 |
Male | 60 (70%) | 43 (70%) | 17 (68%) | 41 (73%) | 19 (63%) | ||
Age | |||||||
<60 years | 54 (63%) | 43 (70%) | 11 (44%) | 0.028 | 37 (66%) | 17 (57%) | 0.484 |
≥60 years | 32 (37%) | 18 (30%) | 14 (56%) | 19 (34%) | 13 (43%) | ||
Asbestos exposure | n=72 | ||||||
No | 54 (75%) | 40 (78%) | 14 (67%) | 0.371 | 35 (76%) | 19 (73%) | 0.784 |
Yes | 18 (25%) | 11 (22%) | 7 (33%) | 11 (24%) | 7 (27%) | ||
Mean peritoneal cancer index (range) | 23 (8–39) | 22 (8–39) | 25 (11–39) | 0.165 | 22 (8–39) | 25 (12–39) | 0.151 |
Completeness of cytoreduction scores | n=72 | ||||||
0 or 1 | 67 (81%) | 47 (80%) | 20 (83%) | 1.000 | 47 (87%) | 20 (69%) | 0.078 |
2 or 3 | 16 (19%) | 12 (20%) | 4 (17%) | 7 (13%) | 9 (31%) | ||
Histologic subtype | |||||||
Epithelioid | 75 (87%) | 53 (87%) | 22 (88%) | 1.000 | 49 (88%) | 26 (87%) | 1.000 |
Non-epithelioid | 11 (13%) | 8 (13%) | 3 (12%) | 7 (12%) | 4 (13%) | ||
Extent of invasion | |||||||
Limited to adipose tissue | 46 (53%) | 32 (52%) | 14 (56%) | 0.815 | 30 (54%) | 16 (53%) | 1.000 |
Extension into the visceral parenchyma | 40 (47%) | 29 (48%) | 11 (44%) | 26 (46%) | 14 (47%) | ||
Lymph node metastasis | n=48 | ||||||
No | 34 (71%) | 23 (72%) | 11 (69%) | 1.000 | 23 (70%) | 11 (73%) | 1.000 |
Yes | 14 (29%) | 9 (28%) | 5 (31%) | 10 (30%) | 4 (27%) | ||
