Table 3 Association of H3K36me3 with renal cell carcinoma-specific survival or progression-free survival, adjusted for age and stratified by SSIGN group

From: Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death

H3K36me3 (positive vs negative) (N=1200a,b)

RCC-specific survival

Progression-free survival

 

No. of events

H3K36me3-negative hazard ratio (95% confidence interval)

P-value

No. of events

H3K36me3-negative hazard ratio (95% confidence interval)

P-value

Adjusted for age

 SSIGN 0–3 (N=822)

53

2.18 (1.09–4.36)

0.03

85

2.13 (1.23–3.68)

0.01

 SSIGN 4–7 (N=312)

127

1.45 (1.01–2.07)

0.04

168

1.40 (1.02–1.91)

0.04

 SSIGN 8+ (N=66)

45

1.37 (0.76–2.47)

0.29

50

1.30 (0.75–2.27)

0.36

  1. Abbreviations: H3K36me3, histone 3 lysine 36 trimethylation; SSIGN, stage, size, grade, and necrosis.
  2. aWeak positive and focal negative staining were excluded.
  3. bMissing SSIGN score in five patients.
Back to article page