Table 8 Algorithm for selective DNA-mismatch repair immunohistochemistry in use at Memorial Sloan Kettering Cancer Center
Age <50 years |
Personal or family history suggestive of Lynch syndrome |
Dense peritumoral lymphocytes |
Tumor infiltrating lymphocytes (>40/high power fields) |
Intratumoral heterogeneity |
Multifocal endometrial tumors |
Histological ambiguity |
’Non-endometrioid’ carcinoma in patients <60 years |
Synchronous ovarian clear cell carcinoma |
Lower uterine segment localization |