Table 8 Algorithm for selective DNA-mismatch repair immunohistochemistry in use at Memorial Sloan Kettering Cancer Center

From: Practical issues related to uterine pathology: staging, frozen section, artifacts, and Lynch syndrome

 Age <50 years

 Personal or family history suggestive of Lynch syndrome

 Dense peritumoral lymphocytes

 Tumor infiltrating lymphocytes (>40/high power fields)

 Intratumoral heterogeneity

 Multifocal endometrial tumors

 Histological ambiguity

’Non-endometrioid’ carcinoma in patients <60 years

 Synchronous ovarian clear cell carcinoma

 Lower uterine segment localization

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