Figure 3
Alterations in the NF-κB regulatory pathway in follicular dendritic cell sarcoma and other tumor types. (a) Gene level view of NFKBIA showing the location of each observed mutation. (b) Chromosome level view of chromosome 16 for cases 2 and 4 demonstrating bi-allelic loss of CYLD, as well as flanking one-copy loss of RBL1. (c) Frequency of loss-of-function alterations (bi-allelic loss, frameshift mutation, and nonsense mutation) in the NF-κB regulatory genes NFKBIA, CYLD, and TNFAIP3 across cancer genome studies available in cBioportal, which was used to generate the figure.15 Insets show frequency of alterations in each gene from selected studies. Letters and numbers listed in parentheses indicate the name of the corresponding cell line. ACyC, adenoid cystic carcinoma; BCL, B-cell lymphoma; CCLE, Cancer Cell Line Encyclopedia; CS, carcinosarcoma; DLBC, diffuse large B-cell lymphoma; HL, Hodgkin lymphoma; lung squ, lung squamous cell carcinoma; MM, multiple myeloma; MSKCC, Memorial Sloan Kettering Cancer Center; MICH, University of Michigan; TCGA, The Cancer Genome Atlas.
