Figure 7

Characteristic immunoprofile of high-risk HPV-related (usual type) endocervical adenocarcinomas. Tumor displays diffuse/strong p16 expression (a). High-risk HPV DNA is detected by in situ hybridization (b (punctate nuclear signals)), consistent with the p16 expression pattern. Tumor is essentially negative for ER (c (rare positive patches are present)) and PR (d). Another example has retained expression of ER (e) with loss of expression of PR (f).