Figure 4
Correlation plots for 15 selected genes. The x axis represents the DESeq-normalized RNA-Seq read counts, while the y axis represents the methylation beta values obtained at the specified CpG site using the Infinium Human Methylation 450 microarray. A correlation matrix between each gene expression levels and all methylation probes annotated to each gene was obtained, and the probe with the lowest (most negative) Spearman correlation coefficient (SCC) was selected. A linear regression line with 95% confidence bands (in gray) was fitted to the correlation plot. Point style represents the gastric cancer molecular subtypes.17 CIN, chromosomal instability; EBV, Epstein–Barr virus—positive; GS, genomic stable; MSI, microsatellite instability.
