Figure 1 | Modern Pathology

Figure 1

From: Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation

Figure 1

Expression and localization of NKX6.3 in the stomach. (a) NKX6.3 mRNA expression in the 24 proximal and 31 distal stomach. (b) Of these, proximal and distal stomach with intestinal metaplasia showed significantly reduced NKX6.3 mRNA expression. IM, intestinal metaplasia. (c and d) Intense nuclear NKX6.3 staining was detected in glandular epithelia in the body (c) and pylorus (d) of human stomach. (e and f) In mice, nuclear NKX6.3 staining was also observed in the forestomach, lined by squamous cells (e), and in the glandular stomach (f).

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