Figure 3 | Modern Pathology

Figure 3

From: Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation

Figure 3

Effects of H. pylori on NKX6.3 expression. (a–c) Gastric mucosae from mice infected with CagA (+) H. pylori showed decreased NKX6.3 DNA copy number (a), mRNA transcript (b), and protein expression (c), compared with those of control (cont.). In addition, H. pylori infection decreased SOX2 mRNA expression and increased CDX2 mRNA expression. However, H. pylori infection did not affect the DNA copy numbers of SOX2 and CDX2. (d and e) Scatter plot illustrates that NKX6.3, CDX2 and SOX2 DNA copy number (d) and mRNA expression level (e) were significantly lower in H. pylori CagA-positive (pos.) than in CagA-negative (neg.) human non-cancerous gastric mucosal tissues (P<0.01), but there was no significant differences in the DNA copy number of CDX2 and SOX2 genes.

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