Figure 3 | Modern Pathology

Figure 3

From: Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas

Figure 3

Immunohistochemical features of silent subtype 3 adenomas. All tumors were diffusely positive for Pit-1 (pituitary-specific transcription factor-1) (a). Most tumors revealed focal positivity for estrogen receptor (ER) (b), and variable positivity for one or more of the adenohypophysial hormones of Pit-1 cell lineage: growth hormone (c), prolactin (d), beta-thyroid stimulating hormone (e), as well as alpha-subunit (f). Only three tumors lacked ER and adenohypophysial hormone expression (g), and were only positive for Pit-1. The CAM5.2 antibody revealed predominant perinuclear or diffuse cytoplasmic staining patterns for low molecular weight keratins (h), and five tumors displayed scattered fibrous bodies (h; arrow).

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