Figure 5 | Modern Pathology

Figure 5

From: Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas

Figure 5

Cartoon illustrating silent subtype 3 adenomas in the molecular cytodifferentiation pathways of the adenohypophysis. Silent subtype 3 adenomas are true monomorphous plurihormonal poorly differentiated Pit-1 lineage adenomas, which can be associated with hyperprolactinemia, acromegaly or even hyperthyroidism. GH, growth hormone; Pit-1, pituitary-specific transcription factor-1; PRL, prolactin; SF-1, steroidogenic factor-1; Tpit, T-box transcription factor; TSH, thyroid-stimulating hormone.

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