Table 2 Immunohistochemical and ultrastructural features of 31 silent subtype 3 adenomas

From: Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas

Case no. a

Transcription factors and hormones

MIB-1

CAM5.2

Spheridia (ultrastructure)

1

Pit-1 (diffuse), PRL (patchy), GH (patchy), TSH (focal), ASU (focal)

NA

Perinuclear

NA

2

Pit-1 (diffuse), PRL (focal), TSH (focal)

2%

Perinuclear

Spheridia (+)

3

Pit-1 (diffuse), PRL (few cells), GH (focal), ASU (focal)

3%

Perinuclear

Spheridia (+)

4

Pit-1 (diffuse), ER (focal), GH (focal), ASU (focal)

4%

Negative

NA

5

Pit-1 (diffuse)

5%

Perinuclear

Spheridia (+)

6

Pit-1 (diffuse)

8%

Perinuclear

Spheridia (+)

7

Pit-1 (diffuse), ER (focal), GH (few cells), PRL (few cells)

4%

Diffuse

Spheridia (+)

8

Pit-1 (diffuse), ER (focal), PRL (few cells), TSH (focal), ASU (variable)

3%

Diffuse with scattered fibrous bodies

Spheridia (+)

9

Pit-1 (diffuse), ER (focal), PRL (variable), ASU (focal)

5%

Membranous

Spheridia (+)

10

Pit-1 (diffuse), ER (very focal), GH (variable), PRL (very focal), TSH (variable), ASU (variable)

3%

Diffuse

Spheridia (+)

11

Pit-1 (diffuse), ER (focal), ASU (focal), GH (focal), PRL (focal), TSH (focal)

4%

Perinuclear

Spheridia (+)

12

Pit-1 (diffuse), ER (few tumor cells), GH (variable), PRL (few tumor cells), TSH (variable)

2%

Perinuclear

NA

13

Pit-1 (diffuse), ASU (variable)

5%

Perinuclear and scattered fibrous bodies

NA

14

Pit-1 (diffuse)

3%

Diffuse

NA

15

Pit-1 (diffuse), ASU (focal), GH (few cells)

5%

Diffuse, but variable

NA

16

Pit-1 (diffuse), ASU (patchy)

1%

Diffuse

NA

17

Pit-1 (diffuse), ASU (abundant), PRL (variable)

9%

Diffuse and scattered fibrous bodies

Spheridia (+)

18

Pit-1 (diffuse), ER (focal), GH (variable), PRL (few cells), TSH (variable), ASU (abundant; patchy)

7%

Perinuclear

NA

19

Pit-1 (diffuse), ER (variable), PRL (variable), TSH (variable), ASU (variable)

2%

Diffuse

NA

20

Pit-1 (diffuse), ER (patchy), GH (patchy), PRL (patchy), TSH (patchy), ASU (patchy)

5.5%

Perinuclear and scattered fibrous bodies

NA

21

Pit-1 (diffuse), PRL (focal), TSH (focal), ASU (patchy)

3%

Membranous

NA

22

Pit-1 (diffuse), ER (focal), GH (focal), PRL (focal), ASU (focal), TSH (few cells).

7%

Diffuse

NA

23

Pit-1 (diffuse), GH (focal), TSH (variable), ASU (focal)

3%

Perinuclear

NA

24

Pit-1 (diffuse), GH (variable), TSH (scattered cells), ASU (variable)

5%

Negative

NA

25

Pit-1 (diffuse), ER (patchy), GH (patchy), PRL (patchy), TSH (patchy), ASU (patchy)

2%

Perinuclear

Spheridia (+)

26

Pit-1 (diffuse), ER (focal), GH (focal), PRL (scattered)

4%

Perinuclear

Spheridia (+)

27

Pit-1 (diffuse), ER (variable), GH (variable), PRL (variable)

7%

Perinuclear

NA

28

Pit-1 (diffuse), GH (variable), PRL (variable), TSH (variable)

6%

Diffuse and scattered fibrous bodies

Spheridia (+)

29

Pit-1 (diffuse), ER (patchy), GH (patchy), PRL (patchy), TSH (patchy), ASU (patchy)

2%

Perinuclear

NA

30

Pit-1 (diffuse), ER (few cells), GH (variable), PRL (few), TSH (variable)

1%

Diffuse and perinuclear

NA

31

Pit-1 (diffuse), ER (focal), GH (focal), PRL (few cells), TSH (variable), ASU (patchy)

4%

Negative

Spheridia (+)

  1. Abbreviations: ASU, α-subunit; ER, estrogen receptor; GH, growth hormone; Pit-1, pituitary-specific transcription factor-1; PRL, prolactin; TSH, thyroid-stimulating hormone.
  2. aCases 1–25 correspond to cases 1–25 from Table 1.
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