Figure 2 | Modern Pathology

Figure 2

From: Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas

Figure 2

SMARCA4 (BRG1) and SMARCB1 (INI1) immunostaining in SMARCA4/SMARCA2-deficient dedifferentiated endometrial carcinomas. (a and b) Case 3 showing a complete loss of SMARCA4 nuclear staining in the undifferentiated component (with internal stromal positive control) and intact SMARCA4 nuclear staining in the differentiated endometrioid component. (c and d) Case 3 showing a complete loss of SMARCA4 nuclear staining in the undifferentiated component (with internal stromal positive control) and intact SMARCA4 nuclear staining in the differentiated endometrioid component. (e) Case 7 showing a complete loss of SMARCA4 nuclear staining in the undifferentiated component and intact SMARCA4 nuclear staining in the differentiated endometrioid component. (f) Case 7 showing intact SMARCB1 nuclear staining in both the differentiated endometrioid component and the undifferentiated component.

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