Figure 1 | Modern Pathology

Figure 1

From: Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma

Figure 1

Increased antigen-presenting cell expression in non-defined telomere maintenance mechanism (NDTMM) glioblastoma from RNA-Seq data. Glioblastomas with different telomere maintenance mechanisms were sequenced using RNA-Seq. (a) NDTMM tumors had increased expression of selected antigen-presenting cell markers compared with telomerase (TEL) and alternative lengthening of telomeres (ALT) glioblastoma. (b) NDTMM had increased gene expression for chemokines produced by macrophages (CXCL8), monocyte recruitment (CCL2), transcription factor that activates gene expression during myeloid development (Spi-1 Proto-Oncogene, SPI1), and chaperone that regulates antigen presentation for the immune response (CD74) compared with alternative lengthening of telomeres (ALT) and telomerase (TEL) glioblastoma. *The false discovery rate-adjusted P-value <0.05; **The false discovery rate-adjusted P-value <0.01. Error bars, mean±s.d.; FPKM, fragments per kilobase of transcript per million mapped reads.

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