Figure 3
Increased CD163-positive cells and poorer patient survival associated with telomerase with macrophages glioblastoma. (a) Examples of CD163 staining to illustrate tumors with increased CD163-positive cells in telomerase with macrophages (TELM) tumors with a macrophage/microglia gene signature by RNA-Seq. (b) An Example of CD163 staining in telomerase (TEL) tumors without a macrophage/microglia gene signature by RNA-Seq to illustrate reduced CD163-positive cells. (c) Western blotting to illustrate increased CD163 protein in telomerase with macrophages compared with telomerase tumors. β-Actin, loading control. (d) An increased tumor-associated macrophages content in telomerase with macrophages tumors was associated with poorer patient survival. TEL, telomerase positive with a low content of tumor-associated macrophages; TELM, non-defined telomere maintenance mechanism tumor without alternative lengthening of telomeres-associated promyelocytic leukemia bodies that is potentially telomerase positive with a high content of tumor-associated macrophages.
