Table 1 Clinico-demographic parameters for the five glioblastoma subgroups

From: Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma

 

ALT

ALTM

TEL

TELM

NDTMM-revised

Total number of cases

24

13

51

36

12

Median age (years)

38 (31.5–60)

48 (38–65.5)

60 (54–67)

64 (58–70.75)

66.5 (58.9–71.1)

Median survival (months)

18* (14.41–21.59]

7.66 (6.78–8.54]

11# (9.43–12.57)

6.05 (5.22–6.88)

3.7 (2–5.4)

Surgery only

0

3% (n=2)

3.5% (n=12)

2.5% (n=14)

3% (n=9)

Surgery+radiotherapy

17.6% (n=12)

8% (n=7)

11% (n=19)

6% (n=8)

4.1% (n=3)

Surgery+radiotherapy+TMZ

20.3% (n=12)

10.7% (n=4)

16.5% (n=20)

10.5% (n=14)

0

>24 months survival

29% (n=7)

4 treated with TMZ

0

12% (n=6)

all treated with TMZ

0

0

Near total/total resection

79% (n=19)

77% (n=10)

80% (n=41)

45% (n=16)

75% (n=9)

Partial resection /biopsy combined no. partial: no. biopsy

21% (n=5)

5:0

23% (n=3)

2:1

20% (n=10)

7:3

55%§ (n=20)

14:6

25% (n=3)

2:1

Frontal/temporal location

71% (n=17)

100% (n=13)

57% (n=29)

53% (n=19)

83% (n=10)

Parietal/occipital location

29% (n=7)

0

41% (n=21)

42% (n=15)

13% (n=2)

Other location

0

0

2% (n=1)

6% (n=2)

0

  1. Abbreviations: ALT, an alternative lengthening of telomeres-associated promyelocytic leukemia bodies positive tumor with a low content of tumor-associated macrophages; ALTM, an alternative lengthening of telomere-associated promyelocytic leukemia bodies positive tumor with a high content of tumor-associated macrophages; NDTMM-revised, a non-defined telomere maintenance mechanism tumor, without alternative lengthening of telomeres-associated promyelocytic leukemia bodies and without increased tumor-associated macrophages; TEL, a telomerase-positive tumor with a low content of tumor-associated macrophages; TELM, an alternative lengthening of telomeres-associated promyelocytic leukemia bodies negative tumor that is potentially telomerase positive with increased tumor-associated macrophages; TMZ, temozolomide; *P<0.05, ALT vs ALTM; #P<0.05, TEL vs TELM; §P<0.05, TELM compared with ALTM, ALT, and TEL.