Figure 4 | Modern Pathology

Figure 4

From: Semi-comprehensive analysis of gene amplification in gastric cancers using multiplex ligation-dependent probe amplification and fluorescence in situ hybridization

Figure 4

A gastric cancer with co-amplification of EGFR and CCND1 in the same nuclei (Case 24). EGFR and CCND1 gene amplification was analyzed by dual-color FISH (a: green fluorescence, EGFR; orange fluorescence, CCND1), and their protein overexpression was analyzed by immunohistochemistry (b, EGFR; c, CCND1). The gene-amplified cells showed 3+-immunostaining of the EGFR and scattered nuclear staining of CCND1.

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