Table 1 Genes with increased copy number (‘amplified’ or ‘gain’) detected by multiplex ligation-dependent probe amplification in advanced gastric cancer
Name of gene | MDM4 | FGF10 | EGFR | MET | SMO | BRAF | FGFR1 | MYC | FGFR2 | CCND1 | CDK4 | MDM2 | ERBB2 | TOP2A | AURKA | AR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chromosomal locus of gene | 1q32.1 | 5p13 | 7p11.2 | 7q31.2 | 7q32.3 | 7q34 | 8p11.23 | 8q24.13 | 10q26 | 11q13.3 | 12q14.1 | 12q15 | 17q12 | 17q21.2 | 20q13.31 | Xq12 |
FISH probe | RP11-430C7 | RP11-273G19 | RP11-339F13 | RP11-75I20 | RP11-152K21 | RP11-1065D4 | RP11-148D21 | RP11-440N18 | RP11-62L18 | RP11-300I6 | RP11-571M6 | RP11-775J10 | RP11-62N23 | RP11-480O10 | RP11-75K20 | RP11-80F19 |
No. of 'amplified' tumors | 0 | 2 (2) | 1 (1) | 1 (1) | 0 | 0 | 0 | 3 (3) | 4 (4) | 3 (3) | 0 | 1 (1) | 11 (11) | 4 (4) | 0 | 0 |
No. of 'gain' tumors | 8 (0) | 5 (1) | 5 (0) | 4 (3) | 2 (0) | 16 (0) | 2 (0) | 10 (6) | 10 (5) | 0 (0) | 2 (0) | 19 (3) | 5 (3) | 13 (4) | 15 (0) | 21 (0) |
