Table 3 Advanced gastric cancers with gene amplification
Case No. | Histological classification | Anatomic stage /prognostic groups | Neoajduvant therapy | FISH findings of amplified genes | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ERBB2 | TOP2A | FGFR2 | MET | EGFR | MYC | MDM2 | CCND1 | FGF10 | ||||
1 | Tub | IV | HSR (>70) | |||||||||
2 | Tub | IV | DCS | HSR (>70) | HSR (>70) | |||||||
3 | Por | IV | DCS/Herceptin | DM (>70) | ||||||||
4 | Tub | IV | Low amp (30–70) | HSR (30–70) | ||||||||
5 | Tub | IV | HSR (>70) | Low amp (>70) | ||||||||
6 | Tub | IV | DCS | HSR (>70) | Low amp (>70) | |||||||
7 | Tub | IIIC | DCS | HSR (30–70) | DM (30–70) | |||||||
8 | Tub | IIIB | DCS | DM (>70) | DM (30–70) | |||||||
9 | Tub | IIIB | S-1 | Co-amp HSR (>70) | co-amp HSR (>70) | High poly (>70) | Low amp (>70) | |||||
10 | Tub | IIIA | Low amp (>70) | Low amp (>70) | ||||||||
11 | Tub | IIIA | HSR (>70) | HSR (>70) | ||||||||
12 | Tub | IIA | Co-amp HSR (>70) | co-amp HSR (>70) | HSR (>70) | |||||||
13 | Tub | IIA | HSR (30-70) | |||||||||
14 | Por | IV | DM (30-70) | |||||||||
15 | Por | IV | High poly (30–70) | HSR (30–70) | ||||||||
16 | Por | IIIB | DCS | DM (30–70) | ||||||||
17 | Por | IIIA | DM (<30) | DM (<30) | ||||||||
18 | Por | IIA | HSR (>70) | |||||||||
19 | Tub | IIA | DM (30-70) | |||||||||
20 | Por | IV | DCS | Low amp (>70) | ||||||||
21 | Tub | IV | DCS | DM (30–70) | ||||||||
22 | Por | IV | DCS | HSR (30–70) | ||||||||
23 | Muc | IIIA | HSR (30–70) | |||||||||
24 | Tub | IIIA | DM (>70) | HSR (>70) | ||||||||
25 | Por | IV | DCS | HSR (>70) | ||||||||
26 | Por | IV | DM>>HSR (30–70) | HSR (>70) | ||||||||
27 | Por | IIIB | S-1/DOC | DM (30–70) | ||||||||
28 | Pap | IIB | HSR (30–70) | |||||||||
29 | Por | IIIA | DCS | Low amp> DM (>70) | ||||||||
30 | Tub | IV | Low amp (>70) | |||||||||
31 | Por | IIA | DCS | DM (30–70) | ||||||||
32 | Mixed | IIIA | DCS | Low amp (>70) | ||||||||
Numbers of cases with gene amplification | 13 | 7 | 7 | 4 | 1 | 7 | 4 | 3 | 2 | |||
Fraction (%) of cases with gene amplification | 14 | 8 | 8 | 4 | 1 | 8 | 4 | 3 | 3 | |||
