Figure 3

Pathway analysis reveals downregulation of RNA polymerase II elongation genes in TCEB1-mutated tumors. (a) Heatmap of mRNA expression of RNA polymerase II elongation genes stratified by TCEB1 mutation and concomitant loss of heterozygosity (loss of heterozygosity), loss of heterozygosity alone, and in the wild-type setting. (b) Box plot of specific RNA polymerase II elongation genes demonstrating a lack of expression changes in tumors with a loss of heterozygosity alone compared with combined TCEB1 mutation and loss of heterozygosity.