Table 1 Morphological and immunohistochemical features of TCEB1-mutated tumors in the Sato and TCGA datasets
From: TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype
Case # | Fibromuscular bands | Nodular configuration | Architectural patterns (in descending order)* | Clear cells with voluminous cytoplasm and prominent borders | ccPRCC-like nuclear arrangement | HIF-1a (% positive cells) | CA-IX (% positive cells) | CK7 (% positive cells) | CD10 (% positive cells) | 34be12 (% positive cells) |
|---|---|---|---|---|---|---|---|---|---|---|
1 | + | + | TU/BTU, Cystic, Pap | + | − | 85 | 100 | 60 | 15 | 0 |
2 | + | + | TU/BTU, Pap, Acinar, Cystic | + | − | 20 | 100 | 40 | 3 | 0 |
3 | + | + | Cystic, TU/BTU, Acinar | + | + | 95 | 100 | 75 | 40 | 10 |
4 | + | + | Cystic, TU/BTU, Sol alv, | + | − | 75 | 100 | 10 | 40 | 0 |
5 | + | + | Tu/BTU, Cystic, Acinar | + | − | 20 | 100 | 80 | 50 | 0 |
6 | + | + | TU/BTU, Solid alv, Acinar, Cystic, Pap | + | + | 70 | 100 | 8 | 0 | 0 |
7 | + | + | TU/BTU, Cystic, Pap | + | + | 35 | 100 | 85 | 20 | 0 |
8 | + | + | Solid alv, Acinar, TU/BTU, Cystic | + | − | 80 | 100 | 12 | 8 | 0 |
9 | + | + | TU/BTU, Sol alv, Acinar, Cystic, Pap | + | − | ND | ND | ND | ND | ND |
10 | + | + | Pap, Acinar, Cystic, TU/BTU | + | − | ND | ND | ND | ND | ND |
