Table 3 Comparative features of TCEB1-mutated and clear cell papillary renal cell carcinoma
From: TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype
Features | Clear cell papillary renal cell carcinoma | TCEB1-mutated renal cell carcinoma |
|---|---|---|
Morphological | ||
Fibromuscular bands | May be present | Present in all tumors |
Fibromuscular bands imparting a multinodular appearance | No/very uncommon | Present in all tumors |
Branching tubules and papillations | Present | Present |
Linear arrangement of nuclei away from basement membrane | Always present, diffusely | May be present, focally |
Voluminous cytoplasm with prominent cell membranes | Not present | Present at least focally in all tumors |
Immunohistochemical | ||
CK7 | Always diffusely positive (in almost 100% cells) | Positive, in variable proportion of cells (not 100% cells) |
Carbonic anhydrase-IX | Always diffusely positive, in a cup-shaped pattern (luminal membranes mostly do not stain) | Always diffusely positive, in a box-shaped pattern (all membranes stain) |
CD10 | Usually negative; rarely, focally positive | Variably positive in most tumors |
High molecular weight cytokeratin (34be12) | Positive in a majority of tumors | Usually negative |
