Figure 3 | Modern Pathology

Figure 3

From: BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations

Figure 3

(a–d) Examples of three BAP1-negative malignant epithelioid and biphasic mesotheliomas. (a) The BAP1-positive lung parenchyma (upper left) infiltrated by the mesothelioma (lower right); (b) BAP1 is expressed by inflammatory cells and vascular endothelium within the tumor. (c and d) A case of biphasic mesothelioma double stained for BAP1 (brown) and epithelial membrane antigen (blue), the latter being helpful to identify the BAP1-negative spindle cells in the sarcomatoid areas. (e and f) The only two cases of epithelioid mesothelioma containing distinct tumor populations regarding BAP1 expression.

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