Figure 4 | Modern Pathology

Figure 4

From: BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations

Figure 4

BAP1 immunostain on cytological (a) and cell-block (b) samples from two cases of epithelioid mesothelioma showing BAP1-negative malignant cells surrounded by numerous BAP1-positive inflammatory cells. Double stain for BAP1 (brown) and CD11c (blue) reveals the histiocytic nature of the BAP1-positive cells embedding the tumor papillae (b). (c–h) Shown is a patient (no. 42 in Table 2) who showed pleural effusion containing rare atypical cells (c) that resulted negative for BAP1 (d, single immunostain for BAP1; e, double immunostain for BAP1 and cytokeratin 5/6, respectively brown and blue); pleural biopsy was unremarkable (f); 11 months later, frank invasive BAP1-negative mesothelioma was diagnosed (g and h).

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