Table 3 Protein expression and genetic aberrations with respect to NF-κB subunit expression

From: Evaluation of NF-κB subunit expression and signaling pathway activation demonstrates that p52 expression confers better outcome in germinal center B-cell-like diffuse large B-cell lymphoma in association with CD30 and BCL2 functions

 

All patients, N (%)

p50+, N (%)

p52+, N (%)

p65+, N (%)

RELB+, N (%)

c-Rel+, N (%)

p50+/p65+, N (%)

p50+/c-Rel+, N (%)

p52+/RELB+, N (%)

Patients

533 (100)

150 (34)

56 (12)

92 (20)

64 (14)

103 (23)

48 (11)

49 (11)

13 (3)

GCB

280 (54)

65 (44)

35 (65)

55 (60)

32 (50)

49 (48)

25 (52)

19 (40)

8 (62)

ABC

243 (46)

84 (56)*

21 (35)

37 (40)

32 (50)

53 (52)

23 (48)

29 (60)*

5 (38)

CD30+

66 (14)

19 (14)

22 (42)*

9 (12)

15 (27)*

15 (16)

6 (15)

7 (17)

8 (67)*

CD30−

391 (86)

115 (86)

30 (58)

68 (88)

41 (73)

76 (84)

34 (85)

35 (83)

4 (33)

pSTAT3+

65 (16)

22 (16)

7 (38)

11 (14)

13 (24)

12 (13)

8 (18)

5 (12)

0 (0)

pSTAT3−

348 (84)

115 (84)

38 (62)

65 (86)

42 (76)

82 (87)

36 (82)

38 (88)

9 (100)

BCL2+

225 (49)

60 (44)

16 (31)

32 (41)

25 (44)

44 (48)

14 (34)

21 (50)

5 (42)

BCL2−

232 (51)

75 (56)

36 (69)*

47 (59)

32 (56)

47 (52)

27 (66)

21 (50)

7 (58)

BCL6+

417 (82)

118 (80)

45 (82)

76 (84)

52 (81)

81 (79)

39 (83)

38 (79)

11 (85)

BCL6−

93 (18)

29 (20)

10 (18)

15 (16)

12 (19)

21 (21)

8 (17)

10 (21)

2 (15)

MYC+

293 (64)

82 (61)

29 (56)

53 (67)

41 (72)

46 (51)

27 (66)

21 (50)

7 (58)

MYC−

164 (36)

52 (39)

23 (44)

26 (33)

16 (38)

45 (49)*

14 (34)

21 (50)*

5 (42)

BCL2 rearranged

77 (19)

15 (12)*

3 (6)*

16 (21)

8 (15)

15 (16)

7 (17)

6 (14)

0 (0)

BCL2 normal

335 (81)

115 (88)

48 (94)

61 (79)

44 (85)

78 (84)

34 (83)

38 (86)

12 (100)

BCL6 rearranged

119 (34)

41 (39)

13 (32)

27 (40)

18 (40)

24 (30)

14 (41)

17 (45)

3 (43)

BCL6 normal

235 (66)

65 (61)

27 (68)

40 (60)

27 (60)

57 (70)

20 (59)

21 (55)

4 (57)

MYC rearranged

38 (9)

8 (6)

1 (2)

6 (8)

3 (6)

5 (5)

3 (8)

1 (2)

0 (0)

MYC normal

386 (91)

118 (94)

46 (98)

68 (92)

48 (94)

86 (95)

36 (92)

41 (98)

10 (100)

TP53 mutation

107 (23)

30 (22)

9 (17)

19 (24)

11 (19)

24 (26)

9 (22)

11 (26)

1 (8)

TP53 wild type

362 (77)

106 (78)

44 (83)

60 (76)

46 (81)

67 (74)

32 (78)

31 (74)

11 (92)

TP53 deletion

55 (14)

16 (12)

7 (13)

8 (9)

7 (12)

15 (15)

6 (14)

9 (19)

2 (15)

TP53 normal

329 (86)

118 (88)

46 (87)

77 (91)

52 (88)

83 (85)

38 (86)

38 (81)

11 (85)

p53+

163 (36)

40 (30)

16 (30)

26 (34)

17 (30)

27 (30)

11 (28)

13 (32)

0 (0)

p53−

285 (64)

93 (70)

37 (70)

51 (66)

40 (70)

63 (70)

29 (72)

28 (68)

12 (100)

  1. Abbreviations: ABC, activated B-cell-like subtype; BCL, B-cell lymphoma; GCB, germinal center B-cell-like subtype; pSTAT, phosphorylated signal transducer and activator of transcription 3.
  2. *P<0.05.
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