Figure 1 | Modern Pathology

Figure 1

From: Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma

Figure 1Figure 1

Histology and immunohistochemistry of metanephric adenoma. (a) Distinct interface between tumor and uninvolved renal parenchyma (H&E). (b) Papillary structures with dystrophic calcification. (c) Tightly packed acini. (d) Papillary structures with more edematous stroma. (e) WT1 shows nuclear positivity. (f) AMACR is negative in tumor cells and positive in normal renal tubules. (g) CD57 shows cytoplasmic positivity. (h) CK7 is negative in tumor cells and positive in normal renal tubules. (i) Fluorescence in situ hybridization with centromeric probes for chromosomes 7 (red signal) and 17 (green signal) show normal nuclei with two red and two green signals. (j) Fluorescence in situ hybridization with centromeric probe for the Y chromosome (green signal) shows normal nuclei with one green signal.

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