Table 3 Summary of immunohistochemical staining properties in metanephric adenoma, papillary renal cell carcinoma, and epithelial-predominant nephroblastoma

From: Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma

Antibody

Staining characteristics a

Metanephric adenoma, n=35b (%)

Papillary renal cell carcinoma, n=15c (%)

Epithelial-predominant nephroblastoma, n=20 (%)

WT1

Negative

0

15 (100)

0

 

Focal

0

0

0

 

Intermediate

3 (9)

0

2 (10)

 

Diffuse

32 (91)

0

18 (90)

AMACR

Negative

34 (97)

0

20 (100)

 

Focal

1 (3)

0

0

 

Intermediate

0

0

0

 

Diffuse

0

15 (100)

0

CK7

Negative

35 (100)

1 (7)

19 (95)

 

Focal

0

0

0

 

Intermediate

0

0

1 (5)

 

Diffuse

0

14 (93)

0

CD57

Negative

0

14 (93)

4 (20)

 

Focal

0

1 (7)

10 (50)

 

Intermediate

0

0

2 (10)

 

Diffuse

35 (100)

0

4 (20)

  1. aScoring: Diffuse >50%, intermediate 26–50%, focal 1–25%, negative <1%.
  2. bTwo tumors were reclassified as papillary renal cell carcinoma and were excluded from analysis with metanephric adenomas.
  3. cThe two reclassified tumors were analyzed in the papillary renal cell carcinoma category.
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