Figure 3
From: Distinct methylation profiles characterize fusion-positive and fusion-negative rhabdomyosarcoma
Development of a DNA methylation signature distinguishing fusion-positive from fusion-negative rhabdomyosarcoma. (a) DNA methylation levels of the 11 CpG sites in this DNA methylation signature. (b and c) Unsupervised clustering of these 11 CpG sites in 37 rhabdomyosarcoma tumors (b) and 10 rhabdomyosarcoma cell lines (c). The fusion-positive and fusion-negative rhabdomyosarcoma samples are shown as red and blue rectangles, respectively, above the heat map. (d) Unsupervised clustering of gene expression of these 11 genes in 58 rhabdomyosarcoma tumor samples. The 33 fusion-positive rhabdomyosarcoma samples and 25 fusion-negative rhabdomyosarcoma samples are labeled as red and blue rectangles above the heat map. The clustering algorithm was based on Pearson's correlation distance metric and Ward linkage on scaled probe-expression data. FN, fusion-negative rhabdomyosarcoma; FP, fusion-positive rhabdomyosarcoma.
