Figure 1
From: Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
(a and b) Pigmented hepatocellular adenoma. This pigmented hepatocellular neoplasm shows no cytological or architectural atypia. Mild fatty change is present (a, 400 ×). (b) (100 ×) Another example of an inflammatory-type hepatocellular adenoma with patchy pigmentation (arrowheads), inflammation, sinusoidal dilatation, and an abortive portal tract (structure composed of arterial branches invested in connective tissue and mild inflammation, but lacking a native bile duct. It is typically seen in inflammatory-type hepatocellular adenoma and is indicated here by an arrow) are evident. Reticulin stain showed an overall intact reticulin meshwork in all pigmented hepatocellular adenomas (not shown). (c and d) Pigmented hepatocellular neoplasm of uncertain malignant potential: this pigmented hepatocellular neoplasm shows evident cytological atypia but no significant architectural abnormalities by H&E (c, 200 ×) and has an overall intact reticulin meshwork (d: 100 ×); the atypia falls short of a diagnosis of hepatocellular carcinoma, and a diagnosis of hepatocellular neoplasm of uncertain malignant potential was rendered. (e–g) Pigmented hepatocellular carcinoma. this pigmented hepatocellular neoplasm demonstrates thick trabecular growth (e, 200 ×) and marked cytological atypia (e, 200 × and f, 400 ×). A reticulin stain (g, 40 ×) shows marked reduction of reticulin within the lesion; the H&E and reticulin findings are consistent with hepatocellular carcinoma.
