Figure 2
From: Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
Hepatocellular carcinoma arising in hepatocellular adenoma. All cases of hepatocellular carcinoma arising in hepatocellular adenoma showed a ‘nodule in nodule’ growth (a, hepatocellular adenoma on the right and hepatocellular carcinoma on the left side, 40 ×). A reticulin stain (b, 40 ×) of this same area shows reticulin loss in the hepatocellular carcinoma component (b, left) and reticulin retention in the hepatocellular adenoma component (b, right). Although atypia is absent in the hepatocellular adenoma component (c, 200 ×), the hepatocellular carcinoma component shows evident atypia (D, 200 ×) and cholestasis (d, arrow).
