Table 1 Summary of histological and immunohistochemical features of pigmented hepatocellular neoplasms
From: Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
Pigmented hepatocellular neoplasms | |||
|---|---|---|---|
Classification | Hepatocellular adenoma (11) | Hepatocellular neoplasm of uncertain malignant potential (7) | Hepatocellular carcinoma (9) |
Average age | 39±11 years | 45±17 years | 32±18 years |
Gender | 11 Female | 5 Female 2 Male | 5 Female 4 Male |
Average size | 7.8±4.3 cm | 6±4.6 cm | 9.9±7.1 cm |
Multiple lesions | 6 (55%) | 3 (43%) | 1 (11%) |
Pigment score (number of lesions) | 1 (6) 2 (2) 3 (3) | 1 (2) 2 (4) 3 (1) | 1 (4) 2 (2) 3 (3) |
Cytological atypia | None | 2 of 7 (29%) | 6 of 9 (67%) |
Architectural atypia | None | 5 of 7 (71%) | 7 of 9 (78%) |
Reticulin | Intact (11 of 11, 100%) | 6 (86%) intact 1 (14%) focally disrupted | 4 (44%) focally disrupted 5 (56%) diffusely disrupted |
Ki-67 | <1% (11 of 11, 100%) | <1% in 6 (86%) 2% in 1 (14%) | <1% in 8 (89%) 7% in 1 (11%) |
Immunohistochemical profile | HNF-1α inactivated (8, 73%) Inflammatory (1, 9%) HNF-1α inactivated and β-catenin activated (1, 9%) Inflammatory and β-catenin activated (1, 9%) | HNF-1α inactivated (4, 57%) Inflammatory (2, 29%) β-catenin activated (1, 14%) | HNF-1α inactivated (1, 11%) Inflammatory (1, 11%) β-catenin activated (6, 67%) Unclassified (1, 11%) |
