Table 3 Differential oncogene expression and amplification
ALT/WDLPS, N=68 (%) | DDLPS, N=48 (%) | P, Pearson's exact test | |
|---|---|---|---|
IHC CDK4 | 0.2 | ||
Null | 10 (40) | 3 (16) | |
Positive | 15 (60) | 16 (84) | |
IHC MDM2 | 0.02 | ||
Null | 8 (22) | 0 (0) | |
Positive | 28 (78) | 21 (100) | |
IHC HMGA2 | 1 | ||
Null | 1 (7) | 2 (12) | |
Positive | 12 (93) | 15(88) | |
FISH CDK4 | 0.007 | ||
Not amplified | 23 (41) | 4 (12) | |
Amplified | 33 (59) | 30 (88) | |
Region upstream to 5′-UTR of HMGA2 | 0.1 | ||
Not amplified | 29 (50) | 10 (30) | |
Amplified | 29 (50) | 23 (70) | |
5′-UTR and exons 1 and 2 of HMGA2 | 0.8 | ||
Not amplified | 6 (12) | 6 (16) | |
Amplified | 43 (88) | 31(84) | |
5′-UTR and exons 1–3 of HMGA2 | 0.01 | ||
Not amplified | 2 (5) | 8 (25) | |
Amplified | 41 (95) | 24(75) | |
Intron 3 and exon 4 of HMGA2 | 0.2 | ||
Not amplified | 6 (14) | 9 (28) | |
Amplified | 38 (86) | 23(72) | |
Exons 4 and 5 and 3′-UTR of HMGA2 | 0.15 | ||
Not amplified | 7 (35) | 3 (14) | |
Amplified | 13 (65) | 19 (86) | |
3′-UTR of HMGA2 | 0.3 | ||
Not amplified | 14 (24) | 12 (36) | |
Amplified | 44 (76) | 21 (64) | |
FISH JUN | 0.005 | ||
Not amplified | 15 (83) | 15 (39) | |
Amplified | 3 (17) | 23 (60) |
