Figure 2
From: Assessment of a HER2 scoring system for colorectal cancer: results from a validation study
Atypical pattern of heterogeneous ERBB2 expression and amplification in colorectal cancer (a–c) and liver metastasis (d–f) from a single patient (#01114) clearly shows clusters of tumor cells with different immunoreactivity ranging from 0 to 3+, corresponding to areas of high (arrows) and no amplification. (a, b, d, e) ERBB2 protein expression by VENTANA 4B5 at x4 (a, d) and x20 (b, e). (c, f) ERBB2 gene copy number by fluorescent in situ hybridization at x63 magnification.
