Figure 3
Expression of K19, epithelial cell adhesion molecule (EpCAM), and carbonic anhydrase-IX (CAIX), and their value in predicting outcome in resected HCCs (cohort 3, n=339). Venn diagram (a) and bar graphs (b) demonstrating the correlation between K19, EpCAM, and CAIX expression in HCCs. (c) Survival curves showing decreased disease-specific survival or extrahepatic recurrence-free survival in K19-positive and CAIX-positive HCCs. (d) Time-dependent iAUC analysis for extrahepatic recurrence, showing the increased iAUC value for TNM stage combined with the CAIX status in comparison with the TNM stage alone. (e) Kaplan–Meier plot of extrahepatic recurrence-free survival according to the TNM stage and CAIX expression status. *P<0.05. HCC, hepatocellular carcinoma; iAUC, integrative area under the curve.
