Figure 3

Histopathological features of solitary fibrous tumors with the –124C>T TERT promoter mutation. (a) A 5.6-cm pleural-based, moderate-risk, classical solitary fibrous tumor in a 78-year-old female (patient P17) that resulted in multiple metastatic pleural nodules and eventually death 144 months after diagnosis. The inset shows a STAT6-immunostained section. (b) A 14-cm histologically malignant pleural solitary fibrous tumor in a 67-year-old man (patient P23). The tumor recurred 9 years later and caused death. The inset shows a STAT6-immunostained section. (c) An 11-cm histologically malignant abdominal wall solitary fibrous tumor in a 77-year-old man (patient S35) that metastasized to the femur and eventually caused death 30 months after diagnosis. (d) A 6-cm histologically classical moderate-risk solitary fibrous tumor in the posterior mediastinum of a 71-year-old woman (patient P24) that resulted in local relapse in 4 years and persistent disease at last follow-up. (e) A 22-cm histologically malignant solitary fibrous tumor in the chest wall of a 55-year-old man (patient S18), which resulted in hypoglycemia symptoms at presentation and local recurrence 66 months after resection. (f) A 2.5-cm solitary fibrous tumor with cellular features in the perirenal fat of a 35-year-old man (patient S43) with no evidence of recurrence 35 months after excision.