Figure 5
From: TERT promoter mutations and prognosis in solitary fibrous tumor
Histopathological features of clinically aggressive solitary fibrous tumors with the wild-type TERT promoter. (a, b). A 15-cm histologically malignant pleural solitary fibrous tumor with marked nuclear pleomorphism (a) and strong p53 expression by immunohistochemistry (b) in a 78-year-old man (patient P25). The patient succumbed to the disease 41 months after diagnosis. (c, d). A 13-cm clinicopathological high-risk hemangiopericytoma-like solitary fibrous tumor (c) in the buttock of a 63-year-old man (patient S28) with p53 overexpression by immunohistochemistry (d), which resulted in distant metastasis and death 6 months after diagnosis.
