Figure 4 | Modern Pathology

Figure 4

From: Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors

Figure 4

c-kit phosphorylation status according to the transduction of mutant PPP2R1A in T1 cells. In T1 cells transduced with mutant PPP2R1A, phosphorylation at Tyr721 was increased compared with those transduced with wild-type PPP2R1A or GFP. The same phenomenon was observed regarding phosphorylation of Tyr568/570, however, this trend was weaker than Tyr721. On the other hand, in wild-type-transduced cells, phosphorylation was decreased compared with T1-GFP.

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