Figure 1
From: Plasmablastic lymphoma phenotype is determined by genetic alterations in MYC and PRDM1
(a and b) Characteristic phenotypic profile of plasmablastic lymphoma cases with absence of expression of B-cell markers (CD20, PAX5) and overexpression of plasma cell-related antigens (Blimp1, CD38, and CD138). Note the homogeneous expression of proliferation markers (Ki67) and MYC protein. Absence of expression of HHV-8 and ALK are required for the exclusion of other lymphoma types. Note that some cases may express CD10 (Table 1). (c) Fluorescent in situ hybridization for MYC rearrangements using a break apart probe. A split signal is clearly identified in a significant fraction of the nuclei. This pattern was found in 12 cases (46%). (d) Multiple copies of the MYC gene are found in a significant fraction of the nuclei, consistent with gains of MYC locus. This pattern was found in 3 cases (11%).
