Table 1 Clinicopathological features of pT1 colorectal carcinoma stratified by lymph node status
Clinicopathological and molecular feature | Negative for lymph node metastasis (%) | Positive for lymph node metastasis (%) | P-value |
|---|---|---|---|
No. of patients | 88 | 28 | NA |
Gender, male/female | 44 (50)/44 (50) | 18 (64)/10 (36) | 0.2 |
Mean age in years (range) | 65 (40–89) | 60 (16–77) | 0.07 |
Location | |||
Right colon | 47 (53) | 13 (46) | 0.5 |
Left colon/rectum | 41 (47) | 15 (54) | |
Mean size of invasive area in cm (range) | 1.1 (0.1–11.5) | 1.1 (0.2–3.5) | 0.9 |
Grade | |||
Low | 83 (94) | 23 (82) | 0.04 |
High | 5 (6) | 5 (18) | |
Mean depth of submucosal invasion (μm) (range) | 2005 (0–6565) | 3053 (0–8971) | 0.04 |
<1000 μm submucosal invasion | 35 (40) | 5 (19) | 0.04 |
>1000 μm submucosal invasion | 53 (60) | 22 (81) | |
Mean tumor buds per 0.95 mm2 (range) | 2.5 (0–16) | 6.1 (0–19) | 0.002 |
Tumor budding | |||
Low (0–4 per 0.95 mm2) | 71 (81) | 12 (43) | <0.001 |
High (⩾5 per 0.95 mm2) | 17 (19) | 16 (57) | |
Mucinous differentiation | |||
None | 74 (84) | 22 (79) | 0.8 |
1–50% | 10 (11) | 4 (14) | |
>50% | 4 (5) | 2 (7) | |
Lymphatic invasion | 12 (14) | 11 (39) | 0.003 |
Venous invasion | 1 (1) | 2 (7) | 0.08 |
Tumor growth pattern | |||
Non-pedunculated | 62 (70) | 22 (79) | 0.4 |
Pedunculated | 26 (30) | 6 (21) | |
Precursor polyp | |||
Precursor polyp identified | 72 | 25 | 0.2 |
Tubular/tubulovillous adenoma | 68 (94) | 21 (84) | |
Traditional serrated adenoma | 1 (1) | 2 (8) | |
Sessile serrated adenoma | 3 (5) | 2 (8) | |
