Table 1 Clinicopathologic characteristics of colorectal carcinomas according to acetyl-CoA synthetase-2 expression status
Acetyl-CoA synthetase-2-low (n=771) | Acetyl-CoA synthease-2-high (n=335) | P-value | |
|---|---|---|---|
Age, years, median (range) | 60.5±11.3 | 61.5±11.0 | 0.198a |
Sex | 0.987 | ||
Male | 463 (60%) | 201 (60%) | |
Female | 308 (40%) | 134 (40%) | |
Tumor location | 0.596 | ||
Proximal colon | 193 (25%) | 82 (25%) | |
Distal colon | 305 (40%) | 124 (37%) | |
Rectum | 273 (35%) | 129 (38%) | |
Gross pattern | 0.003 | ||
Fungating | 487 (63%) | 242 (72%) | |
Ulcerative | 284 (37%) | 93 (28%) | |
T category | < 0.001 | ||
1,2 | 104 (14%) | 102 (31%) | |
3,4 | 667 (86%) | 233 (69%) | |
N category | < 0.001 | ||
0 | 352 (46%) | 210 (63%) | |
1,2 | 419 (54%) | 125 (37%) | |
M category | 0.001 | ||
0 | 621 (80%) | 298 (89%) | |
1 | 150 (20%) | 37 (11%) | |
Stage | < 0.001 | ||
I, II | 328 (43%) | 199 (59%) | |
III, IV | 443 (57%) | 136 (41%) | |
Differentiation | 0.007 | ||
Well/moderate | 737 (96%) | 331 (99%) | |
Poor | 34 (4%) | 4 (1%) | |
Tumor budding | 0.015 | ||
Absent | 200 (26%) | 111 (33%) | |
Present | 571 (74%) | 224 (67%) | |
Luminal necrosis | 0.439 | ||
Absent | 67 (9%) | 34 (10%) | |
Present | 704 (91%) | 301 (90%) | |
Crohn-like lymphoid reaction | 0.06 | ||
Absent | 645 (84%) | 295 (88%) | |
Present | 126 (16%) | 40 (12%) | |
Tumor-infiltrating lymphocytes | 0.119 | ||
Low (<8/HPF) | 580 (75%) | 237 (71%) | |
High (≥ \8/HPF) | 191 (25%) | 98 (29%) | |
Luminal serration | 0.436 | ||
Absent | 738 (96%) | 324 (97%) | |
Present | 33 (4%) | 11 (3%) | |
Extraglandular mucin | 0.547 | ||
Absent | 676 (88%) | 298 (89%) | |
Present | 95 (12%) | 37 (11%) |
