Table 2 Molecular characteristics of colorectal carcinomas according to acetyl-CoA synthetase-2 expression status
Acetyl-CoA synthetase-2-low (n=771) | Acetyl-CoA synthetase-2-high (n=335) | P-value | |
|---|---|---|---|
CpG island methylator phenotype | 0.008 | ||
CpG island methylator phenotype-negative | 368 (48%) | 133 (40%) | |
CpG island methylator phenotype-low | 356 (46%) | 188 (56%) | |
CpG island methylator phenotype-high | 47 (6%) | 14 (4%) | |
Microsatellite instability | 0.305 | ||
Microsatellite stable | 664 (86%) | 286 (85%) | |
Microsatellite instability-low | 53 (7%) | 18 (6%) | |
Microsatellite instability-high | 54 (7%) | 31 (9%) | |
KRAS mutation (n=1044) | 0.975 | ||
Wild-type | 531 (73%) | 235 (73%) | |
Mutant-type | 193 (27%) | 85 (27%) | |
BRAF mutation (n=979) | 0.279 | ||
Wild-type | 660 (96%) | 276 (94%) | |
Mutant-type | 27 (4%) | 16 (6%) | |
KRT7 (CK7) expression (n=1100) | 0.008 | ||
Negative | 690 (90%) | 317 (95%) | |
Positive | 76 (10%) | 17 (5%) | |
KRT20 (CK20) expression (n=1094) | 0.031 | ||
Intact | 620 (81%) | 289 (87%) | |
Decreased | 141 (19%) | 44 (13%) | |
CDX2 expression (n=1084) | 0.019 | ||
Intact | 718 (93%) | 324 (97%) | |
Decreased | 53 (7%) | 11 (3%) | |
MKI67 (Ki-67) labelling index, median (min–max) | 10.4 (0.10–71.0) | 18.8 (0.1–81.6) | < 0.001a |
